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Mucuna Pruriens: The
Dopamine Connection
by Ray Sahelian, M.D.,
Mucuna pruriens, commonly known
as velvet bean, contains L-Dopa. Mucuna has been used for generations in
India to treat
Parkinson's disease. L-dopa is used to make dopamine, an important
brain chemical involved in mood, sexuality, and movement. Studies in
rats show mucuna pruriens supplements influence dopamine content in the
cortex of the brain. Mucuna pruriens has antioxidant properties.
Parkinson's disease has a low prevalence in India except in the small
Parsi community. Parkinson's disease has been known in India since
ancient days and the powder of Mucuna Pruriens seeds has been used for
its treatment.
Composition of Mucuna Pruriens
Nutritional analysis reveals
mucuna pruriens contains crude protein ranged from 20-29 %, crude lipid
6-7%, total dietary fibre 8-10%, ash 3% and carbohydrates 50-60%.
Mucuna Pruriens and
neurotransmitters
It is widely believed that
mucuna pruriens influences the dopamine system, however there may be
other factors involved. A study was designed to
elucidate the long-term effect of Mucuna pruriens on neurotransmitters
in various regions of the rat brain. Mucuna Pruriens was mixed with rat
chow and fed daily ad lib to rats for 52 weeks. Controls received no
mucuna pruriens. The rats were sacrificed at the end of 52 weeks and the
neurotransmitters were analyzed in the cortex, hippocampus, substantia
nigra and striatum. Oral administration of Mucuna pruriens had a
significant effect on dopamine content in the cortex with no significant
effect on levodopa, norepinephrine or dopamine, serotonin, and their
metabolites. The failure of Mucuna pruriens endocarp to significantly
affect dopamine metabolism in the striatonigral tract along with its
ability to improve Parkinsonian symptoms in the 6-hydorxydopamine animal
model and humans may suggest that its anti-Parkinson effect may be due
to components other than levodopa or that it has a levodopa enhancing
effect.
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