C Among Predictors for Kidney Problems in Women With HIV
have cited hepatitis C virus (Hepatitis C Virus) co-infection as well as
several other factors for causing proteinuria and kidney
failure in women infected with HIV, in a study published in
the January 2002 issue of Kidney International
(Predictors of Proteinuria and Renal Failure Among Women with
HIV Infection, 2002;61(1):195-202).
multicenter team, led by Duke University Medical Center
investigator Lynda Anne Szczech, performed a prospective
evaluation of more than 2,000 female participants in the
Women's Interagency HIV study (WIHS). In their analysis, a
patient's race, Hepatitis C Virus coinfection status, and T-cell count,
among other findings, played prominent roles in the risk of
kidney disease in females infected with HIV. Szczech and
coworkers described the WIHS as a long-term study specifically
targeting the clinical characteristics of HIV and its
progression or regression in females.
the ongoing study, participants are checked bi- annually for
several parameters of HIV pathogenesis, including kidney
function, immune system response, and viral replication. Using
statistical analysis, researchers have outlined several
factors for renal disease and progression in HIV-infected
- Of 2057 HIV-positive women, 32 percent had
proteinuria on initial evaluation. Proteinuria is a
significant sign that the kidneys are not functioning
- Being a black female doubled the risk for
proteinuria, while having CD4 cell counts less than or
equal to 200, having increasing HIV levels, and being
co-infected with Hepatitis C Virus were also proteinuria risk factors.
- With respect to developing renal failure - low
T-cell counts, falling albumin levels, detectable HIV RNA
levels, increasing creatinine levels, and rising systolic
blood pressure levels, in that order, were significant
reduce the risks for kidney disease in HIV positive patients,
Szczech and colleagues proposed that research initiatives
should focus on suppressing HIV RNA levels and improving
immune system response.
Hepatitis Weekly (02.11.02) - Wednesday, February 20, 2002;
Sonia Nichols; Courtesy of the CDC National Center for HIV,
STD and TB Prevention.