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"In 27% of patients with mild chronic hepatitis
C treated with interferon-alpha2b for 6 months, serum alanine aminotransferase
levels permanently returned to normal and viral status remained
negative. The model estimated that interferon-alpha2b treatment
in this population should increase life expectancy by 3.1 years
if given at 20 years of age, by 1.5 years at 35 years of age, and
by 22 days at 70 years of age; discounted marginal cost-effectiveness
ratios are $500, $1900, and $62 000 per year of life gained, respectively.
Varying the long-term response rates and progression rates for mild
and moderate chronic hepatitis to near zero in sensitivity analyses
substantially affected the results: Ratios ranged from $31 000 for
a 20-year-old patient to $640 000 for a 70-year-old patient."
Annals of Internal Medicine Estimates of the Cost-Effectiveness
of a Single Course of Interferon-alpha2b in Patients with Histologically
Mild Chronic Hepatitis C Annals of Internal Medicine 15 November
1997
Modeling helps to determine the cost effectiveness of treatment
and the overall success rate for treatment. They can also be used
to given an estimate of the overall cost to society. Insurance companies
(Actuaries) use such models in determining the rates at which customers
are charged for their polices (life or health).
ADDITIONAL ARTICLES:
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Document Name & Link to Document |
Description |
File Size /Type**
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Can the Model for End-Stage Liver Disease (MELD) Predict
Post-Transplantation |
Can
indicators of liver disease severity before liver
transplantation (OLT) predict the outcome following OLT? Can
pretransplant data predict post-OLT outcomes? The researchers
compared three indices of liver disease severity as predictors
of posttransplant outcome: |
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Hepatitis C Virus-mortality
New York |
New York State Department of Health epidemiologists recently
reviewed and compiled the mortality and complication rates
for hospital patients with hepatitis C (HepC) virus in Upstate
New York.
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Hepatitis
C: The Facts, The Epidemic |
It is suspected that there are, at present, more than 5 million people in the United States that are infected with Hepatitis C, and perhaps as many as 200 million around the world. This makes it one of the greatest public
health threats faced in this century, and perhaps one of the
greatest threats to be faced in the next century.
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Increase in mortality rates from
intrahepatic cholangiocarcinoma in England and Wales 2001;
48:816-20 |
Doubling of deaths from liver cancer in last 30 years
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Scientific
Fraud and Conflict Of Interest In. |
In Business School, (Organizational Behavior) we studied
what can happen to organizations that suffer ethical management
breakdowns (such as Johns
Manville with asbestos, Owens Corning breast implants, etc.).
Nothing illustrates the syndrome of management ethical failure
more clearly than the
current scandal faced by Firestone and Ford.
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Single Motive and Multi-Motive
Processing |
This study considers the impact of behavioral commitment
on the cognitive and affective processing of a persuasive
message advocating influenza vaccination behaviors, and the
resulting impact on the integration of information into attitudes,
behavioral intention, and behavior
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Statistical Methods in Psychology |
In the light of continuing debate over the applications of
significance testing in psychology journals and following
the publication of Cohen's (1994) article, the Board of Scientific
Affairs (BSA) of the American Psychological Association (APA)
convened a committee called the Task Force on Statistical
Inference (TFSI) whose charge was "to elucidate some of the
controversial issues surrounding applications of statistics
including significance testing and its alternatives; alternative
underlying models and data transformation; and newer methods
made possible by powerful computers" (BSA, personal communication,
February 28, 1996).
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Use of Single Data Source Can Significantly Underestimate
Hepatitis C Mortality Rates |
Power Point Presentation |
86 kb pdf |
** In order to view PDF files, you must have Adobe Acrobat Reader installed on
your computer. Many computers already have this software; however, if you need
it, a free copy is available for download at this site: Click
here to get Adobe Acrobat Reader.
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