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“The only thing necessary for these diseases to the triumph is for good people and governments to do nothing.”



Hepatitis C Virus Infection Among Firefighters, Emergency Medical Technicians, and Paramedics --- Selected Locations, United States, 1991—2000

First responders (e.g., firefighters, emergency medical technicians [EMTs], and paramedics) are at risk for occupational exposure to bloodborne pathogens. Recently, CDC has received inquiries from state and local health departments and occupational health services about the prevalence of hepatitis C virus (Hepatitis C Virus) infection among first responders and the need for routine Hepatitis C Virus testing among these workers. This report summarizes the findings of five studies of Hepatitis C Virus infection among first responders. Although some of these workers may need Hepatitis C Virus testing under certain circumstances, this report indicates that first responders are not at greater risk than the general population for Hepatitis C Virus infection; therefore, routine Hepatitis C Virus testing is not warranted. First responders should continue to follow standard precautions to reduce workplace exposure to bloodborne pathogens.

Philadelphia, Pennsylvania

During November--December 1999, Home Access Health Corporation (Hoffman Estates, Illinois)* offered specimen collection kits (Hepatitis C Check™) to 4400 active and retired members of the Philadelphia firefighters union. Respondents telephoned a toll-free number to receive their test results and to answer questions anonymously about nonoccupational risk factors for Hepatitis C Virus infection. According to Home Access®, serum was tested for antibody to Hepatitis C Virus (anti-Hepatitis C Virus) with an enzyme immunoassay (EIA 3.0; Ortho Diagnostic Systems, Inc., Raritan, New Jersey); repeatedly reactive samples were tested with a supplemental recombinant immunoblot assay (RIBA™ 3.0, Chiron Corporation, Emeryville, California). In February 2000, Home Access reported that of 2146 respondents, 97 (4.5%) screened positive for anti-Hepatitis C Virus. The company indicated that this prevalence was 2.5 times higher than the national average of 1.8% (Home Access Health Corporation, personal communication, 2000).

In June 2000, CDC re-analyzed serologic and questionnaire data and found that of 2136 participants, 64 (3.0%) tested anti-Hepatitis C Virus--positive (Table 1). The highest prevalence (4.9%) was among men aged 40--49 years (Figure 1). Risk factors associated with Hepatitis C Virus infection were a history of blood transfusion before 1992 (age-adjusted prevalence ratio [PR]=2.2; 95% confidence interval [CI]=1.2--4.0) and illicit drug use (age-adjusted PR=4.0; 95% CI=2.2--7.1). On the basis of CDC's analysis, the 4.5% prevalence previously reported by Home Access was obtained by classifying as positive samples that tested EIA repeatedly reactive but indeterminate by RIBA, and those that tested EIA repeatedly reactive or EIA initially reactive for which no further testing was done (Table 2).


Atlanta, Georgia

In 1991, CDC conducted a voluntary, anonymous survey among metropolitan Atlanta uniformed fire department personnel to assess occupational and nonoccupational risk factors for hepatitis B virus (HBV) infection (1). In May 2000, stored serum samples were tested at CDC for anti-Hepatitis C Virus using EIA 3.0; repeatedly reactive samples were tested by RIBA 3.0. Of the 437 firefighters tested, nine (2.1%) were anti-Hepatitis C Virus--positive; the highest prevalence (4.0%) was among men aged 35--39 years. Hepatitis C Virus infection was not associated with duration of employment as a firefighter, occupational exposures to blood, history of blood transfusion, or illicit drug use; however, Hepatitis C Virus infection was associated with a history of a sexually transmitted disease (PR=7.4; 95% CI=1.6--35.3).


In 1992, Connecticut Department of Public Health and Addiction Services collected serum samples and demographic data on a voluntary basis from first responders in various regions in Connecticut for a study on the immune response to hepatitis B vaccine (2). In June 2000, stored serum samples from the 1992 study were tested anonymously at CDC for anti-Hepatitis C Virus by EIA 3.0 and RIBA 3.0. Among 382 volunteer and professional firefighters and EMTs for whom serum samples were available, five (1.3%) tested anti-Hepatitis C Virus--positive; prevalence was highest (2.6%) among men aged 40--49 years.

Miami-Dade County, Florida

During March--April 2000, Hep-C ALERT, a patient advocacy organization, collaborating with University of Pittsburgh researchers, confidentially obtained serum samples and information on occupational risk factors from Miami-Dade County municipal fire department personnel. Serum samples were tested at a commercial laboratory for anti-Hepatitis C Virus with EIA 3.0; repeatedly reactive samples were tested for Hepatitis C Virus RNA by transcription mediated amplification (TMA™) (Bayer Corporation, Tarrytown, New York). Of the 1314 participants, 35 (2.7%) were anti-Hepatitis C Virus--positive on the basis of EIA testing alone, and 20 (1.5%) were confirmed positive for Hepatitis C Virus RNA. Prevalence of anti-Hepatitis C Virus was highest (3.7%) among men aged >50 years. Increased risk for Hepatitis C Virus infection was not associated with occupational exposures to blood, type of job (firefighter, EMT, or paramedic), or duration of employment as a first responder.

Pittsburgh, Pennsylvania

During January--March 2000, University of Pittsburgh researchers collected serum samples and information on occupational exposures from paramedics working in Pittsburgh. Samples were tested for anti-Hepatitis C Virus by EIA 2.0 (Abbott Laboratories, Abbott Park, Illinois) without supplemental or confirmatory testing. Five (3.2%) of 154 respondents tested anti-Hepatitis C Virus--positive; highest prevalence (5.2%) was among men aged 40--49 years. Anti-Hepatitis C Virus positivity was not associated with occupational exposures to blood.

Reported by: AJ Roome, PhD, HIV/AIDS Surveillance Program, JL Hadler, MD, State Epidemiologist, Connecticut Dept of Public Health. AL Thomas, B Migicovsky, MD, Hep-C ALERT, Miami. MW Dailey, MD, R Roth, MD, Dept of Emergency Medicine, Univ of Pittsburgh; M Boraz, PhD, Graduate School of Public Health, Univ of Pittsburgh; B Kuszajewksi, D Berkowitz, MPH, Bur of Emergency Medical Svcs, City of Pittsburgh, Pennsylvania. Hepatitis Br, Div of Viral and Rickettsial Diseases, National Center for Infectious Diseases; and an EIS Officer, CDC.


Editorial Note: 

Data from the Third National Health and Nutrition Examination Survey (NHANES III), conducted during 1988--1994, indicated that 3.9 million (1.8%) persons living in the United States have been infected with Hepatitis C Virus (3). Estimates indicate that three risk factors accounted for most infections: illicit drug use (60%), high-risk sexual behavior (15%), and blood transfusion (7%) (CDC, unpublished data, 1996; 3,4).

Health-care workers and first responders exposed to blood in the workplace are at risk for infection by bloodborne pathogens. However, their risk for acquiring Hepatitis C Virus infection is low because Hepatitis C Virus is not transmitted efficiently through occupational exposure (4--6). After an unintentional needlestick from an Hepatitis C Virus-positive source, the average risk for Hepatitis C Virus infection is 1.8% (range: 0--7%); transmission rarely occurs from mucous membrane exposures to blood, and no transmission has been documented from intact or nonintact skin exposures to blood (4). Among first responders, Hepatitis C Virus infection was associated primarily with nonoccupational factors, a finding similar to HBV (1), a bloodborne virus that is transmitted at a rate 10 times higher than Hepatitis C Virus (7).

The initial interpretation of the results from the Philadelphia study was incorrect because 20.6% of the serum samples classified as positive were of insufficient volume to complete testing as required by the Food and Drug Administration (FDA). Manufacturer's instructions for performing EIA for anti-Hepatitis C Virus require initially reactive samples to be repeated in duplicate; only samples that are repeatedly reactive are considered EIA-positive. For Hepatitis C Check, FDA-approved conditions for reporting a positive anti-Hepatitis C Virus result require a repeatedly reactive EIA and a positive supplemental test. Samples with insufficient volume for supplemental testing are to be reported as "results not available --- insufficient blood." In populations with an Hepatitis C Virus-infection prevalence of 0--10%, 20%--50% of EIA repeatedly reactive results may be false positives (4,8).

Hepatitis C Virus prevalence reported in studies in subpopulations should be compared with appropriate referent groups from the general population. In NHANES III, conducted during 1988--1994, overall prevalence of Hepatitis C Virus infection among persons of both sexes aged >5 years was 1.8% but was substantially higher (4.9%) among men aged 30--49 years (3), the group that represents most of the first responders in the five studies. Because this group has aged almost 10 years since NHANES III was conducted, men currently aged 40--59 years would have the highest expected prevalence of infection.

Because of several limitations, the five studies could not exclude the possibility that some first responders had acquired Hepatitis C Virus infection from job-related exposures. First, the small sample size and limited information on both occupational (percutaneous, mucosal, or skin exposures to blood) and nonoccupational risk factors may have affected the evaluation of potential sources for infection. Second, the findings do not necessarily represent all first responders in the selected locations or the United States. Third, if first responders are less likely to have nonoccupational risk factors for Hepatitis C Virus infection than the general population, then the expected prevalence in these workers might be lower.

Routine Hepatitis C Virus testing is not recommended for populations with a low prevalence of Hepatitis C Virus infection, including first responders, unless they have a history indicating an increased risk for infection (e.g., transfusion before July 1992 or injecting-drug use) (4). Testing is recommended in first responders for postexposure management after a percutaneous or permucosal exposure to Hepatitis C Virus-positive blood(4), and testing could be considered for these types of exposures when the Hepatitis C Virus status of the source is unknown (9). To reduce workplace exposure to bloodborne pathogens, standard precautions continue to apply; first responders should be educated about transmission of bloodborne pathogens, trained in proper safety measures, and provided with appropriate protective equipment (10). First responders also should be vaccinated against HBV, and informed of protocols if percutaneous or permucosal exposures to blood occur (4,10).