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“The only thing necessary for these diseases to the triumph is for good people and governments to do nothing.”

Pneumonitis during Interferon and/or Herbal Drug Therapy in Patients with Chronic Active Hepatitis.

Ishizaki T.; Sasaki, F.; Ameshima, S.; Shiozaki, K.; Takahashi, H.; Abe, Y.; Ito, S.; Kuriyama, M.; Nakai, T.; Kitagawa, M. "Pneumonitis during Interferon and/or Herbal Drug Therapy in Patients with Chronic Active Hepatitis." European Respiratory Journal, December 1996;9(12):2691-2696.

According to the authors' abstract of an article published in European Respiratory Journal, "We report four cases of acute pneumonitis due either to interferon, or a herbal drug, 'Sho-saikoto', or both in combination, in patients with chronic active hepatitis, focusing on its pathogenesis and response to prednisolone therapy. These cases shared common clinical features: fever, dry cough, dyspnoea. hyperaemia. diffuse infiltrates both on chest radiography and chest computed tomography, restrictive pulmonary functional impairment, and alveolitis on examination of transbronchial lung biopsy, all of which suggest acute interstitial pneumonia. Furthermore, lymphocytosis was observed in association with the dominant CD8[+] T-cell subset in bronchoalveolar lavage fluid. A lymphocyte stimulation test using peripheral blood was positive to interferon in one case and to Sho-saikoto in another. All patients responded to oral prednisolone therapy. Peripheral soluble interleukin-2 receptor levels decreased in parallel with improvement in the clinical course. All patients were free of symptoms with a follow-up of 1-3 yrs. We conclude that interferon- and/or Sho-saikoto-induced acute pneumonitis may be due to allergic-immunological mechanisms rather than toxicity, and that peripheral levels of soluble interleukin-2 receptor appear to be good markers of disease activity." The corresponding author for this study is: T Ishizaki, Fukui Med Sch, Dept Internal Med, Matsuoka. Fukui 9101 I, Japan. For subscription information for this journal contact the publisher. Munksgaard Int Publ Ltd, 35 Norre Sogade, PO Box 2148, DK-1016 Copenhagen, Denmark.

Source: Hepatitis Weekly, 01/27/97, p20, 2/5p.


Item Number: 9702092873